Areas of research

- Risk factors

Alkohol

Antibodies

Workenvironment and chemicals

Genetic markers

Patients' perception

Smoking

Socioekonomic status

Current

Risk factors

Alkohol

Interplay between alcohol, smoking and HLA genes in RA aetiology.

Hedström AK, Hössjer O, Klareskog L, Alfredsson L.

RMD Open. 2019 May 9;5(1):e000893. doi: 10.1136/rmdopen-2019-000893. eCollection 2019.

Long term alcohol intake and risk of rheumatoid arthritis in women: a population based cohort study.

Di Giuseppe D, Alfredsson L, Bottai M, Askling J, Wolk A.

BMJ. 2012 Jul 10;345:e4230. doi: 10.1136/bmj.e4230.

Alcohol consumption is associated with decreased risk of rheumatoid arthritis: results from two Scandinavian case-control studies.

Källberg H, Jacobsen S, Bengtsson C, Pedersen M, Padyukov L, Garred P, Frisch M, Karlson EW, Klareskog L, Alfredsson L.

Ann Rheum Dis. 2009 Feb;68(2):222-7. Epub 2008 Jun 5.Links

Antibodies

Anticitrullinated protein/peptide antibody multiplexing defines an extended group of ACPA-positive rheumatoid arthritis patients with distinct genetic and environmental determinants.

Rönnelid J, Hansson M, Mathsson-Alm L, Cornillet M, Reed E, Jakobsson PJ, Alfredsson L, Holmdahl R, Skriner K, Serre G, Lundberg K, Klareskog L.

Ann Rheum Dis. 2017 Oct 25. pii: annrheumdis-2017-211782. doi: 10.1136/annrheumdis-2017-211782. [Epub ahead of print]

Low levels of antibodies against common viruses associate with anti-citrullinated protein antibody-positive rheumatoid arthritis; implications for disease aetiology.

Sherina N, Hreggvidsdottir HS, Bengtsson C, Hansson M, Israelsson L, Alfredsson L, Lundberg K.

Arthritis Res Ther. 2017 Sep 30;19(1):219. doi: 10.1186/s13075-017-1423-9.

Anticollagen type II antibodies are associated with an acute onset rheumatoid arthritis phenotype and prognosticate lower degree of inflammation during 5 years follow-up.

Manivel VA, Mullazehi M, Padyukov L, Westerlind H, Klareskog L, Alfredsson L, Saevarsdottir S, Rönnelid J.

Ann Rheum Dis. 2017 Mar 23. pii: annrheumdis-2016-210873. doi: 10.1136/annrheumdis-2016-210873. [Epub ahead of print]

Spectrum of Anti Citrullinated Peptide Antibodies (ACPA) fine specificities is different between Malaysian and Swedish rheumatoid arthritis patients: Implications for pathogenesis of RA.

Too CL, Murad S, Hansson M, Alm LM, Dhaliwal JS, Holmdahl R, Jakobsson PJ, Alfredsson L, Klareskog L, Rönnelid J, Padyukov L.

Arthritis Rheumatol. 2016 Aug 2. doi: 10.1002/art.39827. [Epub ahead of print]

Antibodies to carbamylated α-enolase epitopes in rheumatoid arthritis also bind citrullinated epitopes and are largely indistinct from anti-citrullinated protein antibodies.

Reed E, Jiang X, Kharlamova N, Ytterberg AJ, Catrina AI, Israelsson L, Mathsson-Alm L, Hansson M, Alfredsson L, Rönnelid J, Lundberg K.

Arthritis Res Ther. 2016 May 4;18(1):96. doi: 10.1186/s13075-016-1001-6

Antibodies to Porphyromonas gingivalis indicate interaction between oral infection, smoking and risk genes in rheumatoid arthritis etiology.

Kharlamova N, Jiang X, Sherina N, Potempa B, Israelsson L, Quirke AM, Eriksson K, Yucel-Lindberg T, Venables PJ, Potempa J, Alfredsson L, Lundberg K.

Arthritis Rheumatol. 2015 Nov 10. doi: 10.1002/art.39491. [Epub ahead of print]

Associations with smoking and shared epitope differ between IgA- and IgG-class antibodies to cyclic citrullinated peptides in early rheumatoid arthritis.

Svärd A, Skogh T, Alfredsson L, Ilar A, Klareskog L, Bengtsson C, Kastbom A.

Arthritis Rheumatol. 2015 May;67(8):2032-7. doi: 10.1002/art.39170.

Blood autoantibody and cytokine profiles predict response to anti-tumor necrosis factor therapy in rheumatoid arthritis.

Hueber W, Tomooka BH, Batliwalla F, Li W, Monach PA, Tibshirani RJ, Van Vollenhoven RF, Lampa J, Saito K, Tanaka Y, Genovese MC, Klareskog L, Gregersen PK, Robinson WH.

Arthritis Res Ther. 2009;11(3):R76. Epub 2009 May 21

Workenvironment and chemicals

Occupational exposure to organic dusts and risk of developing rheumatoid arthritis: findings from a Swedish population-based case-control study.

Ilar A, Gustavsson P, Wiebert P, Alfredsson L.

RMD Open. 2019 Nov 21;5(2):e001049. doi: 10.1136/rmdopen-2019-001049. eCollection 2019.

Occupational exposure to asbestos and silica and risk of developing rheumatoid arthritis: findings from a Swedish population-based case-control study.

Ilar A, Klareskog L, Saevarsdottir S, Wiebert P, Askling J, Gustavsson P, Alfredsson L.

RMD Open. 2019 Jul 11;5(2):e000978. doi: 10.1136/rmdopen-2019-000978. eCollection 2019.

Airborne Occupational Exposures and Risk of Developing Rheumatoid Arthritis: A Job-Exposure Matrix Approach in a Swedish Population-Based Case-Control Study.

Ilar A, Alfredsson L, Wiebert P, Klareskog L, Bengtsson C.

Arthritis Care Res (Hoboken). 2017 Oct 3. doi: 10.1002/acr.23436. [Epub ahead of print]

Amount of smoking, duration of smoking cessation and their interaction with silica exposure in the risk of rheumatoid arthritis among males: results from the Swedish Epidemiological Investigation of Rheumatoid Arthritis (EIRA) study.

Zeng P, Chen Z, Klareskog L, Alfredsson L, Bengtsson C, Jiang X.

Ann Rheum Dis. 2017 Sep 15. pii: annrheumdis-2017-212145. doi: 10.1136/annrheumdis-2017-212145. [Epub ahead of print] No abstract available.

Relationship between shift work and the onset of rheumatoid arthritis.

Hedström AK, Åkerstedt T, Klareskog L, Alfredsson L.

RMD Open. 2017 Aug 29;3(2):e000475. doi: 10.1136/rmdopen-2017-000475. eCollection 2017.

Working in cold environment and risk of developing rheumatoid arthritis: results from the Swedish EIRA case-control study.

Zeng P, Bengtsson C, Klareskog L, Alfredsson L.

RMD Open. 2017 Aug 16;3(2):e000488. doi: 10.1136/rmdopen-2017-000488. eCollection 2017.

Occupation and Risk of Developing Rheumatoid Arthritis: Results From a Population-Based Case-Control Study.

Ilar A, Alfredsson L, Wiebert P, Klareskog L, Bengtsson C.

Arthritis Care Res (Hoboken). 2017 Aug 10. doi: 10.1002/acr.23321. [Epub ahead of print]

Physical workload is associated with increased risk of rheumatoid arthritis: results from a Swedish population-based case-control study.

Zeng P, Klareskog L, Alfredsson L, Bengtsson C.

RMD Open. 2017 Mar 14;3(1):e000324. doi: 10.1136/rmdopen-2016-000324. eCollection 2017.

Occupational exposure to textile dust increases the risk of rheumatoid arthritis: results from a Malaysian population-based case-control study.

Too CL, Muhamad NA, Ilar A, Padyukov L, Alfredsson L, Klareskog L, Murad S, Bengtsson C; MyEIRA Study Group.

Ann Rheum Dis. 2016 Jun;75(6):997-1002. doi: 10.1136/annrheumdis-2015-208278. Epub 2015 Dec 17

Silica exposure is associated with an increased risk of developing ACPA-positive rheumatoid arthritis in an Asian population: evidence from the Malaysian MyEIRA case-control study.

Yahya A, Bengtsson C, Larsson P, Too CL, Mustafa AN, Abdullah NA, Muhamad NA, Klareskog L, Murad S, Alfredsson L.

Mod Rheumatol. 2013 Apr 25. [Epub ahead of print]

Ambient air pollution exposures and risk of rheumatoid arthritis in the Nurses' Health Study.

Hart JE, Källberg H, Laden F, Costenbader KH, Yanosky JD, Klareskog L, Alfredsson L, Karlson EW.

Arthritis Care Res (Hoboken). 2013 Feb 11. doi: 10.1002/acr.21975. [Epub ahead of print]

Ambient air pollution exposures and risk of rheumatoid arthritis: results from the Swedish EIRA case-control study.

Hart JE, Källberg H, Laden F, Bellander T, Costenbader KH, Holmqvist M, Klareskog L, Alfredsson L, Karlson EW.

Ann Rheum Dis. 2012 Jul 24. [Epub ahead of print]

Usage of skin care products and risk of rheumatoid arthritis: results from the Swedish EIRA study.

Sverdrup BM, Källberg H, Klareskog L, Alfredsson L; Epidemiological Investigation of Rheumatoid Arthritis Study Group.

Arthritis Res Ther. 2012 Feb 28;14(1):R41. [Epub ahead of print]

Common vaccinations among adults do not increase the risk of developing rheumatoid arthritis: results from the Swedish EIRA study.

Bengtsson C, Kapetanovic MC, Källberg H, Sverdrup B, Nordmark B, Klareskog L, Alfredsson L; EIRA Study Group.

Ann Rheum Dis. 2010 Oct;69(10):1831-3. Epub 2010 Jul 5.

Silica exposure among male current smokers is associated with a high risk of developing ACPA-positive rheumatoid arthritis.

Stolt P, Yahya A, Bengtsson C, Källberg H, Rönnelid J, Lundberg I, Klareskog L, Alfredsson L; EIRA Study Group.

Ann Rheum Dis. 2010 Jun;69(6):1072-6. Epub 2009 Dec 4.

Psychosocial stress at work and the risk of developing rheumatoid arthritis: results from the Swedish EIRA study.

Bengtsson C, Theorell T, Klareskog L, Alfredsson L.

Psychother Psychosom. 2009;78(3):193-4. Epub 2009 Mar 24. No abstract available.

Association between occupational exposure to mineral oil and rheumatoid arthritis: results from the Swedish EIRA case-control study.

Sverdrup B, Kallberg H, Bengtsson C, Lundberg I, Padyukov L, Alfredsson L, Klareskog L; Epidemiological Investigation of Rheumatoid Arthritis Study Group.

Arthritis Res Ther. 2005;7(6):R1296-303. Epub 2005 Sep 23.

Silica exposure is associated with increased risk of developing rheumatoid arthritis: results from the Swedish EIRA study.

Stolt P, Kallberg H, Lundberg I, Sjogren B, Klareskog L, Alfredsson L; EIRA study group.

Ann Rheum Dis. 2005 Apr;64(4):582-6. Epub 2004 Aug 19.

Occupation, occupational exposure to chemicals and rheumatological disease. A register based cohort study.
Lundberg I, Alfredsson L, Plato N, Sverdrup B, Klareskog L, Kleinau S.

Scand J Rheumatol. 1994;23(6):305-10.

Genetic markers

Complex Relationships of Smoking, HLA-DRB1 Genes, and Serologic Profiles in Patients With Early Rheumatoid Arthritis: Update From a Swedish Population-Based Case-Control Study.

Hedström AK, Rönnelid J, Klareskog L, Alfredsson L.

Arthritis Rheumatol. 2019 Sep;71(9):1504-1511. doi: 10.1002/art.40852. Epub 2019 Jul 24.

Distinct HLA Associations with Rheumatoid Arthritis Subsets Defined by Serological Subphenotype.

Terao C, Brynedal B, Chen Z, Jiang X, Westerlind H, Hansson M, Jakobsson PJ, Lundberg K, Skriner K, Serre G, Rönnelid J, Mathsson-Alm L, Brink M, Dahlqvist SR, Padyukov L, Gregersen PK, Barton A, Alfredsson L, Klareskog L, Raychaudhuri S.

Am J Hum Genet. 2019 Sep 5;105(3):616-624. doi: 10.1016/j.ajhg.2019.08.002. Epub 2019 Aug 29. Erratum in: Am J Hum Genet. 2019 Oct 3;105(4):880.

Interplay between alcohol, smoking and HLA genes in RA aetiology.

Hedström AK, Hössjer O, Klareskog L, Alfredsson L.

RMD Open. 2019 May 9;5(1):e000893. doi: 10.1136/rmdopen-2019-000893. eCollection 2019.

Systematic approach demonstrates enrichment of multiple interactions between non-HLA risk variants and HLA-DRB1 risk alleles in rheumatoid arthritis.

Diaz-Gallo LM, Ramsköld D, Shchetynsky K, Folkersen L, Chemin K, Brynedal B, Uebe S, Okada Y, Alfredsson L, Klareskog L, Padyukov L.

Ann Rheum Dis. 2018 Oct;77(10):1454-1462. doi: 10.1136/annrheumdis-2018-213412. Epub 2018 Jul 2.

VAV1 regulates experimental autoimmune arthritis and is associated with anti-CCP negative rheumatoid arthritis.

Guerreiro-Cacais AO, Norin U, Gyllenberg A, Berglund R, Beyeen AD; Rheumatoid Arthritis Consortium International (RACI), Petit-Teixeira E, Cornélis F, Saoudi A, Fournié GJ, Holmdahl R, Alfredsson L, Klareskog L, Jagodic M, Olsson T, Kockum I, Padyukov L.

Genes Immun. 2017 Mar;18(2):109. doi: 10.1038/gene.2017.7. No abstract available.

DNA methylation mediates genotype and smoking interaction in the development of anti-citrullinated peptide antibody-positive rheumatoid arthritis.

Meng W, Zhu Z, Jiang X, Too CL, Uebe S, Jagodic M, Kockum I, Murad S, Ferrucci L, Alfredsson L, Zou H, Klareskog L, Feinberg AP, Ekström TJ, Padyukov L, Liu Y.

Arthritis Res Ther. 2017 Mar 29;19(1):71. doi: 10.1186/s13075-017-1276-2.

A genetic risk score composed of rheumatoid arthritis risk alleles, HLA-DRB1 haplotypes, and response to TNFi therapy - results from a Swedish cohort study.

Jiang X, Askling J, Saevarsdottir S, Padyukov L, Alfredsson L, Viatte S, Frisell T.

Arthritis Res Ther. 2016 Dec 3;18(1):288

Non-HLA genes PTPN22, CDK6 and PADI4 are associated with specific autoantibodies in HLA-defined subgroups of rheumatoid arthritis.

Snir O, Gomez-Cabrero D, Montes A, Perez-Pampin E, Gómez-Reino JJ, Seddighzadeh M, Klich KU, Israelsson L, Ding B, Catrina AI, Holmdahl R, Alfredsson L, Klareskog L, Tegnér J, Gonzalez A, Malmström V, Padyukov L.

Arthritis Res Ther. 2014 Aug 20;16(5):414. [Epub ahead of print]

Anti-CarP antibodies in two large cohorts of patients with rheumatoid arthritis and their relationship to genetic risk factors, cigarette smoking and other autoantibodies.

Jiang X, Trouw LA, van Wesemael TJ, Shi J, Bengtsson C, Källberg H, Malmström V, Israelsson L, Hreggvidsdottir H, Verduijn W, Klareskog L, Alfredsson L, Huizinga TW, Toes RE, Lundberg K, van der Woude D.

Ann Rheum Dis. 2014 Oct;73(10):1761-8. doi: 10.1136/annrheumdis-2013-205109. Epub 2014 May 8.

Identification of secreted phosphoprotein 1 gene as a new rheumatoid arthritis susceptibility gene.

Gazal S, Sacre K, Allanore Y, Teruel M, Goodall AH; (The CARDIOGENICS consortium), Tohma S, Alfredsson L, Okada Y, Xie G, Constantin A, Balsa A, Kawasaki A, Nicaise P, Amos C, Rodriguez-Rodriguez L, Chioccia G, Boileau C, Zhang J, Vittecoq O, Barnetche T, Gonzalez Gay MA, Furukawa H, Cantagrel A, Le Loët X, Sumida T, Hurtado-Nedelec M, Richez C, Chollet-Martin S, Schaeverbeke T, Combe B, Khoryati L, Coustet B, El-Benna J, Siminovitch K, Plenge R, Padyukov L, Martin J, Tsuchiya N, Dieudé P.

Ann Rheum Dis. 2014 Jan 21. doi: 10.1136/annrheumdis-2013-204581. [Epub ahead of print]

Genetic risk scores and number of autoantibodies in patients with rheumatoid arthritis.

Maehlen MT, Olsen IC, Andreassen BK, Viken MK, Jiang X, Alfredsson L, Källberg H, Brynedal B, Kurreeman F, Daha N, Toes R, Zhernakova A, Gutierrez-Achury J, de Bakker PI, Martin J, Teruel M, Gonzalez-Gay MA, Rodríguez-Rodríguez L, Balsa A, Uhlig T, Kvien TK, Lie BA.

Ann Rheum Dis. 2013 Dec 13. doi: 10.1136/annrheumdis-2013-204173. [Epub ahead of print]

Identification of anticitrullinated protein antibody reactivities in a subset of anti-CCP-negative rheumatoid arthritis: association with cigarette smoking and HLA-DRB1 'shared epitope' alleles.

Wagner CA, Sokolove J, Lahey LJ, Bengtsson C, Saevarsdottir S, Alfredsson L, Delanoy M, Lindstrom TM, Walker RP, Bromberg R, Chandra PE, Binder SR, Klareskog L, Robinson WH.

Ann Rheum Dis. 2014 Jan 16. doi: 10.1136/annrheumdis-2013-203915. [Epub ahead of print]

Familial risks and heritability of rheumatoid arthritis: role of rheumatoid factor/anti-citrullinated protein antibody status, number and type of affected relatives, sex, and age.

Frisell T, Holmqvist M, Källberg H, Klareskog L, Alfredsson L, Askling J.

Arthritis Rheum. 2013 Nov;65(11):2773-82. doi: 10.1002/art.38097.

Multiplex analyses of antibodies against citrullinated peptides in individuals prior to development of rheumatoid arthritis.

Brink M, Hansson M, Mathsson L, Jakobsson PJ, Holmdahl R, Hallmans G, Stenlund H, Rönnelid J, Klareskog L, Rantapää-Dahlqvist S.

Arthritis Rheum. 2013 Apr;65(4):899-910. doi: 10.1002/art.37835.

Association of environmental and genetic factors and gene-environment interactions with risk of developing rheumatoid arthritis.

Karlson EW, Ding B, Keenan BT, Liao K, Costenbader KH, Klareskog L, Alfredsson L, Chibnik LB.

Arthritis Care Res (Hoboken). 2013 Mar 12. doi: 10.1002/acr.22005. [Epub ahead of print]

Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis.

Liu Y, Aryee MJ, Padyukov L, Fallin MD, Hesselberg E, Runarsson A, Reinius L, Acevedo N, Taub M, Ronninger M, Shchetynsky K, Scheynius A, Kere J, Alfredsson L, Klareskog L, Ekström TJ, Feinberg AP.

Nat Biotechnol. 2013 Jan 20;31(2):142-7. doi: 10.1038/nbt.2487. Epub 2013 Jan 20.

Rare, low-frequency, and common variants in the protein-coding sequence of biological candidate genes from GWASs contribute to risk of rheumatoid arthritis.

Diogo D, Kurreeman F, Stahl EA, Liao KP, Gupta N, Greenberg JD, Rivas MA, Hickey B, Flannick J, Thomson B, Guiducci C, Ripke S, Adzhubey I, Barton A, Kremer JM, Alfredsson L; Consortium of Rheumatology Researchers of North America; Rheumatoid Arthritis Consortium International, Sunyaev S, Martin J, Zhernakova A, Bowes J, Eyre S, Siminovitch KA, Gregersen PK, Worthington J, Klareskog L, Padyukov L, Raychaudhuri S, Plenge RM.

Am J Hum Genet. 2013 Jan 10;92(1):15-27. doi: 10.1016/j.ajhg.2012.11.012. Epub 2012 Dec 20.

Genome-wide association analysis of anti-TNF drug response in patients with rheumatoid arthritis.

Umicevic Mirkov M, Cui J, Vermeulen SH, Stahl EA, Toonen EJ, Makkinje RR, Lee AT, Huizinga TW, Allaart R, Barton A, Mariette X, Miceli CR, Criswell LA, Tak PP, de Vries N, Saevarsdottir S, Padyukov L, Bridges SL, van Schaardenburg DJ, Jansen TL, Dutmer EA, van de Laar MA, Barrera P, Radstake TR, van Riel PL, Scheffer H, Franke B, Brunner HG, Plenge RM, Gregersen PK, Guchelaar HJ, Coenen MJ.

Ann Rheum Dis. 2012 Dec 11. [Epub ahead of print]

Polymorphisms in peptidylarginine deiminase associate with rheumatoid arthritis in diverse Asian populations: evidence from MyEIRA study and meta-analysis.

Too CL, Murad S, Dhaliwal JS, Larsson P, Jiang X, Ding B, Alfredsson L, Klareskog L, Padyukov L.

Arthritis Res Ther. 2012 Nov 19;14(6):R250. [Epub ahead of print]

High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.

Eyre S, Bowes J, Diogo D, Lee A, Barton A, Martin P, Zhernakova A, Stahl E, Viatte S, McAllister K, Amos CI, Padyukov L, Toes RE, Huizinga TW, Wijmenga C, Trynka G, Franke L, Westra HJ, Alfredsson L, Hu X, Sandor C, de Bakker PI, Davila S, Khor CC, Heng KK, Andrews R, Edkins S, Hunt SE, Langford C, Symmons D; Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate; Wellcome Trust Case Control Consortium, Concannon P, Onengut-Gumuscu S, Rich SS, Deloukas P, Gonzalez-Gay MA, Rodriguez-Rodriguez L, Ärlsetig L, Martin J, Rantapää-Dahlqvist S, Plenge RM, Raychaudhuri S, Klareskog L, Gregersen PK, Worthington J.

Nat Genet. 2012 Dec;44(12):1336-40. doi: 10.1038/ng.2462. Epub 2012 Nov 11.

Variants Within STAT Genes Reveal Association with Anticitrullinated Protein Antibody-negative Rheumatoid Arthritis in 2 European Populations.

Seddighzadeh M, Gonzalez A, Ding B, Ferreiro-Iglesias A, Gomez-Reino JJ; Rheumatoid Arthritis Network and Coordinated Project, Klareskog L, Alfredsson L, Dunussi-Joannopoulos K, Clark JD, Padyukov L.

J Rheumatol. 2012 Aug;39(8):1509-16. Epub 2012 Jul 1.

Genetic and environmental determinants for disease risk in subsets of rheumatoid arthritis defined by the anticitrullinated protein/peptide antibody fine specificity profile.

Lundberg K, Bengtsson C, Kharlamova N, Reed E, Jiang X, Kallberg H, Pollak-Dorocic I, Israelsson L, Kessel C, Padyukov L, Holmdahl R, Alfredsson L, Klareskog L.

Ann Rheum Dis. 2012 Sep 8. [Epub ahead of print]

Multifunctional T cell reactivity to native and glycosylated type-II collagen in rheumatoid arthritis.

Snir O, Bäcklund J, Boström J, Andersson I, Kihlberg J, Buckner JH, Klareskog L, Holmdahl R, Malmström V.

Arthritis Rheum. 2012 Mar 5. doi: 10.1002/art.34459. [Epub ahead of print]

Interaction Analysis between HLA-DRB1 Shared Epitope Alleles and MHC Class II Transactivator CIITA Gene with Regard to Risk of Rheumatoid Arthritis.

Ronninger M, Seddighzadeh M, Eike MC, Plant D, Daha NA, Skinningsrud B, Worthington J, Kvien TK, Toes RE, Lie BA, Alfredsson L, Padyukov L.

PLoS One. 2012;7(3):e32861. Epub 2012 Mar 26

Very high level of anti-citrullinated peptide antibodies associate with HLA-DRB1*15 non-shared epitope allele in patients with rheumatoid arthritis.

Laki J, Lundström E, Snir O, Rönnelid J, Ganji I, Catrina AI, Bengtsson C, Saevarsdottir S, Wick MC, Alfredsson L, Klareskog L, Padyukov L.

Arthritis Rheum. 2012 Feb 3. doi: 10.1002/art.34421. [Epub ahead of print]

Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis.

Raychaudhuri S, Sandor C, Stahl EA, Freudenberg J, Lee HS, Jia X, Alfredsson L, Padyukov L, Klareskog L, Worthington J, Siminovitch KA, Bae SC, Plenge RM, Gregersen PK, de Bakker PI.

Nat Genet. 2012 Jan 29;44(3):291-6. doi: 10.1038/ng.1076

Patterns of interaction between genetic and nongenetic attributes and methotrexate efficacy in rheumatoid arthritis.

Dervieux T, Wessels JA, Kremer JM, Padyukov L, Seddighzadeh M, Saevarsdottir S, van Vollenhoven RF, Klareskog L, Huizinga TW, Guchelaar HJ.

Pharmacogenet Genomics. 2012 Jan;22(1):1-9.

Biomarkers and personalised medicine in: a proposal for interactions between academia, industry and regulatory bodies.

Miossec P, Verweij CL, L, Pitzalis C, Barton A, Lekkerkerker F, Reiter S, Laslop A, Breedveld F, Abadie E, Flamion B, Dere W, Mpofu S, Goel N, Ethgen D, Mitlak B, Ormarsdóttir S, Rao R, Tsouderos Y, Reginster JY; on behalf of the Group for the Respect of Ethics and Excellence in Science (GREES).

Ann Rheum Dis. 2011 Oct;70(10):1713-1718. Epub 2011 Jul 22.

Biomarkers and personalised medicine in: a proposal for interactions between academia, industry and regulatory bodies.

Ann Rheum Dis. 2011 Oct;70(10):1713-1718. Epub 2011 Jul 22

GEIRA: gene-environment and gene-gene interaction research application.

Ding B, Källberg H, Klareskog L, Padyukov L, Alfredsson L.

Eur J Epidemiol. 2011 Apr 26. [Epub ahead of print]

GWAS of Follicular Lymphoma Reveals Allelic Heterogeneity at 6p21.32 and Suggests Shared Genetic Susceptibility with Diffuse Large B-cell Lymphoma.

Smedby KE, Foo JN, Skibola CF, Darabi H, Conde L, Hjalgrim H, Kumar V, Chang ET, Rothman N, Cerhan JR, Brooks-Wilson AR, Rehnberg E, Irwan ID, Ryder LP, Brown PN, Bracci PM, Agana L, Riby J, Cozen W, Davis S, Hartge P, Morton LM, Severson RK, Wang SS, Slager SL, Fredericksen ZS, Novak AJ, Kay NE, Habermann TM, Armstrong B, Kricker A, Milliken S, Purdue MP, Vajdic CM, Boyle P, Lan Q, Zahm SH, Zhang Y, Zheng T, Leach S, Spinelli JJ, Smith MT, Chanock SJ, Padyukov L, Alfredsson L, Klareskog L, Glimelius B, Melbye M, Liu ET, Adami HO, Humphreys K, Liu J.

PLoS Genet. 2011 Apr;7(4):e1001378. Epub 2011 Apr 21.

Mannan Binding Lectin (MBL) genotypes coding for high mannan binding lectin (MBL) serum levels are associated with rheumatoid factor negative rheumatoid arthritis in never smokers.

Saevarsdottir S, Ding B, Steinsson K, Grondal G, Valdimarsson H, Alfredsson L, Klareskog L, Padyukov L.

Arthritis Res Ther. 2011 Apr 15;13(2):R65. [Epub ahead of print]

Variants of gene for microsomal prostaglandin E2 synthase show association with disease and severe inflammation in rheumatoid arthritis.

Korotkova M, Daha NA, Seddighzadeh M, Ding B, Catrina AI, Lindblad S, Huizinga TW, Toes RE, Alfredsson L, Klareskog L, Jakobsson PJ, Padyukov L.

Eur J Hum Genet. 2011 Mar 30. [Epub ahead of print]

Effects of GSTM1 in Rheumatoid Arthritis; Results from the Swedish EIRA study.

Lundström E, Hartshorne T, Li K, Lindblad S, Wick MC, Bengtsson C, Alfredsson L, Klareskog L, Padyukov L.

PLoS One. 2011 Mar 22;6(3):e17880.

A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis.

Padyukov L, Seielstad M, Ong RT, Ding B, Rönnelid J, Seddighzadeh M, Alfredsson L, Klareskog L; the Epidemiological Investigation of Rheumatoid Arthritis (EIRA) Study Group.

Ann Rheum Dis. 2010 Dec 14. [Epub ahead of print]

Effect of glutathione S-transferase T1, M1, P1 and heme oxygenase-1 polymorphisms interactionswith heavy smoking on the risk of rheumatoid arthritis.

Keenan BT, Chibnik LB, Cui J, Ding B, Padyukov L, Kallberg H, Bengtsson C, Klareskog L, Alfredsson L, Karlson EW.

Arthritis Rheum. 2010 Jul 1. [Epub ahead of print]

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.

Stahl EA, Raychaudhuri S, Remmers EF, Xie G, Eyre S, Thomson BP, Li Y, Kurreeman FA, Zhernakova A, Hinks A, Guiducci C, Chen R, Alfredsson L, Amos CI, Ardlie KG; BIRAC Consortium, Barton A, Bowes J, Brouwer E, Burtt NP, Catanese JJ, Coblyn J, Coenen MJ, Costenbader KH, Criswell LA, Crusius JB, Cui J, de Bakker PI, De Jager PL, Ding B, Emery P, Flynn E, Harrison P, Hocking LJ, Huizinga TW, Kastner DL, Ke X, Lee AT, Liu X, Martin P, Morgan AW, Padyukov L, Posthumus MD, Radstake TR, Reid DM, Seielstad M, Seldin MF, Shadick NA, Steer S, Tak PP, Thomson W, van der Helm-van Mil AH, van der Horst-Bruinsma IE, van der Schoot CE, van Riel PL, Weinblatt ME, Wilson AG, Wolbink GJ, Wordsworth BP; YEAR Consortium, Wijmenga C, Karlson EW, Toes RE, de Vries N, Begovich AB, Worthington J, Siminovitch KA, Gregersen PK, Klareskog L, Plenge RM.

Nat Genet. 2010 Jun;42(6):508-14. Epub 2010 May 9.

Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapy.

Cui J, Saevarsdottir S, Thomson B, Padyukov L, van der Helm-van Mil AH, Nititham J, Hughes LB, de Vries N, Raychaudhuri S, Alfredsson L, Askling J, Wedrén S, Ding B, Guiducci C, Wolbink GJ, Crusius JB, van der Horst-Bruinsma IE, Herenius M, Weinblatt ME, Shadick NA, Worthington J, Batliwalla F, Kern M, Morgan AW, Wilson AG, Isaacs JD, Hyrich K, Seldin MF, Moreland LW, Behrens TW, Allaart CF, Criswell LA, Huizinga TW, Tak PP, Bridges SL Jr, Toes RE, Barton A, Klareskog L, Gregersen PK, Karlson EW, Plenge RM.

Arthritis Rheum. 2010 Jul;62(7):1849-61.

Cumulative association of 22 genetic variants with seropositive rheumatoid arthritis risk.

Karlson EW, Chibnik LB, Kraft P, Cui J, Keenan BT, Ding B, Raychaudhuri S, Klareskog L, Alfredsson L, Plenge RM.

Ann Rheum Dis. 2010 Jun;69(6):1077-85. Epub 2010 Mar 16.

Analysis of neuropeptide S receptor gene (NPSR1) polymorphism in rheumatoid arthritis.

D'Amato M, Zucchelli M, Seddighzadeh M, Anedda F, Lindblad S, Kere J, Alfredsson L, Klareskog L, Padyukov L.

PLoS One. 2010 Feb 22;5(2):e9315.

Evidence for interaction between 5-hydroxytryptamine (serotonin) receptor 2A and MHC type II molecules in the development of rheumatoid arthritis.

Seddighzadeh M, Korotkova M, Källberg H, Ding B, Daha N, Kurreeman FA, Toes RE, Huizinga TW, Catrina AI, Alfredsson L, Klareskog L, Padyukov L.

Eur J Hum Genet. 2010 Feb 24. [Epub ahead of print]

Protection from ACPA-positive rheumatoid arthritis (RA) is predominantly associated with HLA-DRB1*1301: "A meta-analysis of HLA-DRB1 associations with ACPA-positive and ACPA-negative RA in four European populations"

van der Woude D, Lie BA, Lundström E, Balsa A, Feitsma AL, Houwing-Duistermaat JJ, Verduyn W, Nordang GB, Alfredsson L, Klareskog L, Pascual-Salcedo D, Gonzalez-Gay MA, Lopez-Nevot MA, Valero F, Roep BO, Huizinga TW, Kvien TK, Martín J, Padyukov L, de Vries RR, Toes RE.

Arthritis Rheum. 2010 Jan 29. [Epub ahead of print]

Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.

Raychaudhuri S, Thomson BP, Remmers EF, Eyre S, Hinks A, Guiducci C, Catanese JJ, Xie G, Stahl EA, Chen R, Alfredsson L, Amos CI, Ardlie KG; BIRAC Consortium, Barton A, Bowes J, Burtt NP, Chang M, Coblyn J, Costenbader KH, Criswell LA, Crusius JB, Cui J, De Jager PL, Ding B, Emery P, Flynn E, Harrison P, Hocking LJ, Huizinga TW, Kastner DL, Ke X, Kurreeman FA, Lee AT, Liu X, Li Y, Martin P, Morgan AW, Padyukov L, Reid DM, Seielstad M, Seldin MF, Shadick NA, Steer S, Tak PP, Thomson W, van der Helm-van Mil AH, van der Horst-Bruinsma IE, Weinblatt ME, Wilson AG, Wolbink GJ, Wordsworth P; YEAR Consortium, Altshuler D, Karlson EW, Toes RE, de Vries N, Begovich AB, Siminovitch KA, Worthington J, Klareskog L, Gregersen PK, Daly MJ, Plenge RM.

Nat Genet. 2009 Dec;41(12):1313-8. Epub 2009 Nov 8.PMID: 19898481

Specific interaction between genotype, smoking and autoimmunity to citrullinated alpha-enolase in the etiology of rheumatoid arthritis.

Mahdi H, Fisher BA, Källberg H, Plant D, Malmström V, Rönnelid J, Charles P, Ding B, Alfredsson L, Padyukov L, Symmons DP, Venables PJ, Klareskog L, Lundberg K.

Nat Genet. 2009 Dec;41(12):1319-1324. Epub 2009 Nov 8.PMID: 19898480

Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases.

International MHC and Autoimmunity Genetics Network, Rioux JD, Goyette P, Vyse TJ, Hammarström L, Fernando MM, Green T, De Jager PL, Foisy S, Wang J, de Bakker PI, Leslie S, McVean G, Padyukov L, Alfredsson L, Annese V, Hafler DA, Pan-Hammarström Q, Matell R, Sawcer SJ, Compston AD, Cree BA, Mirel DB, Daly MJ, Behrens TW, Klareskog L, Gregersen PK, Oksenberg JR, Hauser SL.

Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18680-5. Epub 2009 Oct 21.PMID: 19846760 [PubMed - in process]

Gene-environment interaction between the DRB1 shared epitope and smoking in the risk of anti-citrullinated protein antibody-positive rheumatoid arthritis: all alleles are important.

Lundström E, Källberg H, Alfredsson L, Klareskog L, Padyukov L.

Arthritis Rheum. 2009 Jun;60(6):1597-603.

The PRL -1149 G/T polymorphism and rheumatoid arthritis susceptibility.

Lee YC, Raychaudhuri S, Cui J, de Vivo I, Ding B, Alfredsson L, Padyukov L, Costenbader KH, Seielstad M, Graham RR, Klareskog L, Gregersen PK, Plenge RM, Karlson EW.

Arthritis Rheum. 2009 May;60(5):1250-4.

Opposing effects of HLA-DRB1*13 alleles on the risk of developing anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis.

Lundström E, Källberg H, Smolnikova M, Ding B, Rönnelid J, Alfredsson L, Klareskog L, Padyukov L.

Arthritis Rheum. 2009 Apr;60(4):924-30.

Different patterns of associations with anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis in the extended major histocompatibility complex region.

Ding B, Padyukov L, Lundström E, Seielstad M, Plenge RM, Oksenberg JR, Gregersen PK, Alfredsson L, Klareskog L.

Arthritis Rheum. 2009 Jan;60(1):30-8.

Common variants at CD40 and other loci confer risk of rheumatoid arthritis.

Raychaudhuri S, Remmers EF, Lee AT, Hackett R, Guiducci C, Burtt NP, Gianniny L, Korman BD, Padyukov L, Kurreeman FA, Chang M, Catanese JJ, Ding B, Wong S, van der Helm-van Mil AH, Neale BM, Coblyn J, Cui J, Tak PP, Wolbink GJ, Crusius JB, van der Horst-Bruinsma IE, Criswell LA, Amos CI, Seldin MF, Kastner DL, Ardlie KG, Alfredsson L, Costenbader KH, Altshuler D, Huizinga TW, Shadick NA, Weinblatt ME, de Vries N, Worthington J, Seielstad M, Toes RE, Karlson EW, Begovich AB, Klareskog L, Gregersen PK, Daly MJ, Plenge RM.

Nat Genet. 2008 Oct;40(10):1216-23. Epub 2008 Sep 14.

A candidate gene approach identifies the TRAF1/C5 region as a risk factor for rheumatoid arthritis.

Kurreeman FA, Padyukov L, Marques RB, Schrodi SJ, Seddighzadeh M, Stoeken-Rijsbergen G, van der Helm-van Mil AH, Allaart CF, Verduyn W, Houwing-Duistermaat J, Alfredsson L, Begovich AB, Klareskog L, Huizinga TW, Toes RE.

PLoS Med. 2007 Sep;4(9):e278. Erratum in: PLoS Med. 2007 Dec;4(12):e358.

Genetic variations in the serotonin 5-HT2A receptor gene (HTR2A) are associated with rheumatoid arthritis.

Kling A, Seddighzadeh M, Arlestig L, Alfredsson L, Rantapää-Dahlqvist S, Padyukov L.

Ann Rheum Dis. 2008 Aug;67(8):1111-5. Epub 2007 Nov 15.

Two independent alleles at 6q23 associated with risk of rheumatoid arthritis.

Plenge RM, Cotsapas C, Davies L, Price AL, de Bakker PI, Maller J, Pe'er I, Burtt NP, Blumenstiel B, DeFelice M, Parkin M, Barry R, Winslow W, Healy C, Graham RR, Neale BM, Izmailova E, Roubenoff R, Parker AN, Glass R, Karlson EW, Maher N, Hafler DA, Lee DM, Seldin MF, Remmers EF, Lee AT, Padyukov L, Alfredsson L, Coblyn J, Weinblatt ME, Gabriel SB, Purcell S, Klareskog L, Gregersen PK, Shadick NA, Daly MJ, Altshuler D.

Nat Genet. 2007 Dec;39(12):1477-82. Epub 2007 Nov 4.

A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity.

Olsson LM, Lindqvist AK, Källberg H, Padyukov L, Burkhardt H, Alfredsson L, Klareskog L, Holmdahl R.

Arthritis Res Ther. 2007;9(5):R98.

TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study. Plenge RM, Seielstad M, Padyukov L, Lee AT, Remmers EF, Ding B, Liew A, Khalili H, Chandrasekaran A, Davies LR, Li W, Tan AK, Bonnard C, Ong RT, Thalamuthu A, Pettersson S, Liu C, Tian C, Chen WV, Carulli JP, Beckman EM, Altshuler D, Alfredsson L, Criswell LA, Amos CI, Seldin MF, Kastner DL, Klareskog L, Gregersen PK.

N Engl J Med. 2007 Sep 20;357(12):1199-209. Epub 2007 Sep 5.

Association of arthritis with a gene complex encoding C-type lectin-like receptors.

Lorentzen JC, Flornes L, Eklöw C, Bäckdahl L, Ribbhammar U, Guo JP, Smolnikova M, Dissen E, Seddighzadeh M, Brookes AJ, Alfredsson L, Klareskog L, Padyukov L, Fossum S.

Arthritis Rheum. 2007 Aug;56(8):2620-32.

Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritis.

Sigurdsson S, Padyukov L, Kurreeman FA, Liljedahl U, Wiman AC, Alfredsson L, Toes R, Rönnelid J, Klareskog L, Huizinga TW, Alm G, Syvänen AC, Rönnblom L.

Arthritis Rheum. 2007 Jul;56(7):2202-10.

Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis.

Kallberg H, Padyukov L, Plenge RM, Ronnelid J, Gregersen PK, van der Helm-van Mil AH, Toes RE, Huizinga TW, Klareskog L, Alfredsson L; Epidemiological Investigation of Rheumatoid Arthritis study group.

Am J Hum Genet. 2007 May;80(5):867-75. Epub 2007 Apr 2.

Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4.

Plenge RM, Padyukov L, Remmers EF, Purcell S, Lee AT, Karlson EW, Wolfe F, Kastner DL, Alfredsson L, Altshuler D, Gregersen PK, Klareskog L, Rioux JD.

Am J Hum Genet. 2005 Dec;77(6):1044-60. Epub 2005 Nov 1.

Association of the PD-1.3A allele of the PDCD1 gene in patients with rheumatoid arthritis negative for rheumatoid factor and the shared epitope.

Prokunina L, Padyukov L, Bennet A, de Faire U, Wiman B, Prince J, Alfredsson L, Klareskog L, Alarcon-Riquelme M.

Arthritis Rheum. 2004 Jun;50(6):1770-3.

Diet

Mediterranean diet and risk of rheumatoid arthritis: a population-based case-control study.

Johansson K, Askling J, Alfredsson L, Di Giuseppe D; EIRA study group.

Arthritis Res Ther. 2018 Aug 9;20(1):175. doi: 10.1186/s13075-018-1680-2.

Are dietary vitamin D, omega-3 fatty acids and folate associated with treatment results in patients with early rheumatoid arthritis? Data from a Swedish population-based prospective study.

Lourdudoss C, Wolk A, Nise L, Alfredsson L, Vollenhoven RV.

BMJ Open. 2017 Jun 10;7(6):e016154. doi: 10.1136/bmjopen-2017-016154.

Dietary Intake of Polyunsaturated Fatty Acids and Pain in spite of Inflammatory Control among Methotrexate Treated Early Rheumatoid Arthritis Patients.

Lourdudoss C, Di Giuseppe D, Wolk A, Westerlind H, Klareskog L, Alfredsson L, van Vollenhoven RF, Lampa J.

Arthritis Care Res (Hoboken). 2017 Mar 28. doi: 10.1002/acr.23245. [Epub ahead of print]

Dietary Fish and Fish Oil and the Risk of Rheumatoid Arthritis.

Rosell M, Wesley AM, Rydin K, Klareskog L, Alfredsson L; the EIRA study group.

Epidemiology. 2009 Aug 27. [Epub ahead of print]

Patients' perception

Patients' conceptions of the cause of their rheumatoid arthritis: A qualitative study.

Bergsten U, Bergman S, Fridlund B, Alfredsson L, Berglund A, Petersson IF, Arvidsson B; the EIRA Study Group.

Musculoskeletal Care. 2009 May 18. [Epub ahead of print]

Smoking

Complex Relationships of Smoking, HLA-DRB1 Genes, and Serologic Profiles in Patients With Early Rheumatoid Arthritis: Update From a Swedish Population-Based Case-Control Study.

Hedström AK, Rönnelid J, Klareskog L, Alfredsson L.

Arthritis Rheumatol. 2019 Sep;71(9):1504-1511. doi: 10.1002/art.40852. Epub 2019 Jul 24.

Interplay between alcohol, smoking and HLA genes in RA aetiology.

Hedström AK, Hössjer O, Klareskog L, Alfredsson L.

RMD Open. 2019 May 9;5(1):e000893. doi: 10.1136/rmdopen-2019-000893. eCollection 2019.

Interplay between obesity and smoking with regard to RA risk.

Hedström AK, Klareskog L, Alfredsson L.

RMD Open. 2019 Apr 16;5(1):e000856. doi: 10.1136/rmdopen-2018-000856. eCollection 2019.

Exposure to passive smoking and rheumatoid arthritis risk: results from the Swedish EIRA study.

Hedström AK, Klareskog L, Alfredsson L.

Ann Rheum Dis. 2018 Jul;77(7):970-972. doi: 10.1136/annrheumdis-2018-212973. Epub 2018 May 3.

Smoking and susceptibility to rheumatoid arthritis in a Swedish population-based case-control study.

Hedström AK, Stawiarz L, Klareskog L, Alfredsson L.

Eur J Epidemiol. 2018 Apr;33(4):415-423. doi: 10.1007/s10654-018-0360-5. Epub 2018 Jan 31.

Seropositivity combined with smoking is associated with increased prevalence of periodontitis in patients with rheumatoid arthritis.

Eriksson K, Nise L, Alfredsson L, Catrina AI, Askling J, Lundberg K, Klareskog L, Yucel-Lindberg T.

Ann Rheum Dis. 2017 Oct 6. pii: annrheumdis-2017-212091. doi: 10.1136/annrheumdis-2017-212091. [Epub ahead of print]

Zeng P, Chen Z, Klareskog L, Alfredsson L, Bengtsson C, Jiang X.

Ann Rheum Dis. 2017 Sep 15. pii: annrheumdis-2017-212145. doi: 10.1136/annrheumdis-2017-212145. [Epub ahead of print] No abstract available.

High sodium chloride consumption enhances the effects of smoking but does not interact with SGK1 polymorphisms in the development of ACPA-positive status in patients with RA.

Jiang X, Sundström B, Alfredsson L, Klareskog L, Rantapää-Dahlqvist S, Bengtsson C.

Ann Rheum Dis. 2016 May;75(5):943-6. doi: 10.1136/annrheumdis-2015-209009. Epub 2016 Feb 22. No abstract available

An Immunochip-based interaction study of contrasting interaction effects with smoking in ACPA-positive versus ACPA-negative rheumatoid arthritis.

Jiang X, Källberg H, Chen Z, Ärlestig L, Rantapää-Dahlqvist S, Davila S, Klareskog L, Padyukov L, Alfredsson L.

Rheumatology (Oxford). 2016 Jan;55(1):149-55. doi: 10.1093/rheumatology/kev285. Epub 2015 Aug 13.

Interactions Between Amino Acid-Defined Major Histocompatibility Complex Class II Variants and Smoking in Seropositive Rheumatoid Arthritis.

Kim K, Jiang X, Cui J, Lu B, Costenbader KH, Sparks JA, Bang SY, Lee HS, Okada Y, Raychaudhuri S, Alfredsson L, Bae SC, Klareskog L, Karlson EW.

Arthritis Rheumatol. 2015 Oct;67(10):2611-23. doi: 10.1002/art.39228.

Associations with smoking and shared epitope differ between IgA- and IgG-class antibodies to cyclic citrullinated peptides in early rheumatoid arthritis.

Svärd A, Skogh T, Alfredsson L, Ilar A, Klareskog L, Bengtsson C, Kastbom A.

Arthritis Rheumatol. 2015 May;67(8):2032-7. doi: 10.1002/art.39170.

Smokeless tobacco (moist snuff) use and the risk of developing rheumatoid arthritis: Results from the Swedish Epidemiological Investigation of Rheumatoid Arthritis (EIRA) case-control study.

Jiang X, Alfredsson L, Klareskog L, Bengtsson C.

Arthritis Care Res (Hoboken). 2014 Apr 9. doi: 10.1002/acr.22325. [Epub ahead of print]

Cigarette smoking and smoking cessation in relation to risk of rheumatoid arthritis in women.

Di Giuseppe D, Orsini N, Alfredsson L, Askling J, Wolk A.

Arthritis Res Ther. 2013 Apr 22;15(2):R56. [Epub ahead of print]

Smoking interacts with HLA-DRB1 shared epitope in the development of anti-citrullinated protein antibody-positive rheumatoid arthritis: results from the Malaysian Epidemiological Investigation of Rheumatoid Arthritis (MyEIRA).

Too CL, Yahya A, Murad S, Dhaliwal JS, Larsson PT, Muhamad NA, Abdullah NA, Mustafa AN, Klareskog L, Alfredsson L, Padyukov L, Bengtsson C; MyEIRA study group.

Arthritis Res Ther. 2012 Apr 26;14(2):R89. [Epub ahead of print]

Smoking is associated with an increased risk of developing ACPA-positive but not ACPA-negative rheumatoid arthritis in Asian populations: evidence from the Malaysian MyEIRA case-control study.

Yahya A, Bengtsson C, Lai TC, Larsson PT, Mustafa AN, Abdullah NA, Muhamad N, Hussein H, Klareskog L, Alfredsson L, Murad S.

Mod Rheumatol. 2011 Oct 18. [Epub ahead of print]

Smoking, citrullination and genetic variability in the immunopathogenesis of rheumatoid arthritis.

Klareskog L, Malmström V, Lundberg K, Padyukov L, Alfredsson L.

Semin Immunol. 2011 Mar 2. [Epub ahead of print]

Smoking is a major preventable risk factor for rheumatoid arthritis: estimations of risks after various exposures to cigarette smoke.

Källberg H, Ding B, Padyukov L, Bengtsson C, Rönnelid J, Klareskog L, Alfredsson L; EIRA Study Group.

Ann Rheum Dis. 2010 Dec 13. [Epub ahead of print]

Patients with early rheumatoid arthritis who smoke are less likely to respond to treatment with methotrexate and TNF inhibitors. Observations from the EIRA cohort and the Swedish Rheumatology Register.

Saevarsdottir S, Wedrén S, Seddighzadeh M, Bengtsson C, Wesley A, Lindblad S, Askling J, Alfredsson L, Klareskog L.

Arthritis Rheum. 2010 Sep 22. [Epub ahead of print]

Silica exposure among male current smokers is associated with a high risk of developing ACPA positive rheumatoid arthritis.

Stolt P, Yahya A, Bengtsson C, Källberg H, Rönnelid J, Lundberg I, Klareskog L, Alfredsson L, Study Group TE.

Ann Rheum Dis. 2009 Dec 4. [Epub ahead of print]PMID: 19966090

Smoking as a trigger for inflammatory rheumatic diseases.

Klareskog L, Padyukov L, Alfredsson L.

Curr Opin Rheumatol. 2007 Jan;19(1):49-54. Review.

A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination.

Klareskog L, Stolt P, Lundberg K, Kallberg H, Bengtsson C, Grunewald J, Ronnelid J, Harris HE, Ulfgren AK, Rantapaa-Dahlqvist S, Eklund A, Padyukov L, Alfredsson L.

Arthritis Rheum. 2006 Jan;54(1):38-46

A gene-environment interaction between smoking and shared epitope genes in HLA-DR provides a high risk of seropositive rheumatoid arthritis.

Padyukov L, Silva C, Stolt P, Alfredsson L, Klareskog L.

Arthritis Rheum. 2004 Oct;50(10):3085-92.

Quantification of the influence of cigarette smoking on rheumatoid arthritis: results from a population based case-control study, using incident cases.
Stolt P, Bengtsson C, Nordmark B, Lindblad S, Lundberg I, Klareskog L, Alfredsson L; EIRA study group.

Ann Rheum Dis. 2003 Sep;62(9):835-41. Review.

Socioeconomic status

Socioeconomic status and the risk of developing rheumatoid arthritis: results from the Swedish EIRA study.

Bengtsson C, Nordmark B, Klareskog L, Lundberg I, Alfredsson L; EIRA Study Group.

Ann Rheum Dis. 2005 Nov;64(11):1588-94. Epub 2005 Apr 20.

Weight

Response to: 'Obesity and comorbidity are independently associated with a failure to achieve remission in patients with established rheumatoid arthritis' by Ellerby et al.

Sandberg ME, Bengtsson C, Källberg H, Wesley A, Klareskog L, Alfredsson L, Saevarsdottir S.

Ann Rheum Dis. 2014 Sep 26. pii: annrheumdis-2014-206369. doi: 10.1136/annrheumdis-2014-206369. [Epub ahead of print] No abstract available.

Overweight decreases the chance of achieving good response and low disease activity in early rheumatoid arthritis.

Sandberg ME, Bengtsson C, Källberg H, Wesley A, Klareskog L, Alfredsson L, Saevarsdottir S.

Ann Rheum Dis. 2014 May 12. doi: 10.1136/annrheumdis-2013-205094. [Epub ahead of print]

Association between overweight, obesity, ACPA positive and ACPA negative Rheumatoid Arthritis-, results from the EIRA case-control study.

Wesley A, Bengtsson C, Elkan AC, Klareskog L, Alfredsson L, Wedrén S; EIRA study group.

Arthritis Care Res (Hoboken). 2012 Jun 5. doi: 10.1002/acr.21749. [Epub ahead of print]

Reviews

Oral contraceptives, breastfeeding and the risk of developing rheumatoid arthritis: results from the Swedish EIRA study.

Orellana C, Saevarsdottir S, Klareskog L, Karlson EW, Alfredsson L, Bengtsson C.

Ann Rheum Dis. 2017 Nov;76(11):1845-1852. doi: 10.1136/annrheumdis-2017-211620. Epub 2017 Aug 17.

Remaining Pain in Early Rheumatoid Arthritis Patients Treated With Methotrexate.

Altawil R, Saevarsdottir S, Wedrén S, Alfredsson L, Klareskog L, Lampa J.

Arthritis Care Res (Hoboken). 2016 Aug;68(8):1061-8. doi: 10.1002/acr.22790.

Parity influences the severity of ACPA-negative early rheumatoid arthritis: a cohort study based on the Swedish EIRA material.

Pikwer M, Orellana C, Källberg H, Pikwer A, Turesson C, Klareskog L, Alfredsson L, Saevarsdottir S, Bengtsson C.

Arthritis Res Ther. 2015 Dec 12;17:358. doi: 10.1186/s13075-015-0869-x

Higher education is associated with a better rheumatoid arthritis outcome concerning for pain and function but not disease activity: results from the EIRA cohort and Swedish rheumatology register.

Jiang X, Sandberg ME, Saevarsdottir S, Klareskog L, Alfredsson L, Bengtsson C.

Arthritis Res Ther. 2015 Nov 6;17:317. doi: 10.1186/s13075-015-0836-6.

Postmenopausal hormone therapy and the risk of rheumatoid arthritis: results from the Swedish EIRA population-based case-control study.

Orellana C, Saevarsdottir S, Klareskog L, Karlson EW, Alfredsson L, Bengtsson C.

Eur J Epidemiol. 2015 May;30(5):449-57. doi: 10.1007/s10654-015-0004-y. Epub 2015 Mar 12.

To what extent is the familial risk of rheumatoid arthritis explained by established rheumatoid arthritis risk factors?

Jiang X, Frisell T, Askling J, Karlson EW, Klareskog L, Alfredsson L, Källberg H.

Arthritis Rheumatol. 2015 Feb;67(2):352-62. doi: 10.1002/art.38927.

Improved performance of epidemiologic and genetic risk models for rheumatoid arthritis serologic phenotypes using family history.

Sparks JA, Chen CY, Jiang X, Askling J, Hiraki LT, Malspeis S, Klareskog L, Alfredsson L, Costenbader KH, Karlson EW.

Ann Rheum Dis. 2014 Apr 30. doi: 10.1136/annrheumdis-2013-205009. [Epub ahead of print]

Patients with regular physical activity before onset of rheumatoid arthritis present with milder disease.

Sandberg ME, Wedrén S, Klareskog L, Lundberg IE, Opava CH, Alfredsson L, Saevarsdottir S.

Ann Rheum Dis. 2014 Aug;73(8):1541-4. doi: 10.1136/annrheumdis-2014-205180. Epub 2014 Mar 18.

Parity and the risk of developing rheumatoid arthritis: results from the Swedish Epidemiological Investigation of Rheumatoid Arthritis study.

Orellana C, Wedrén S, Källberg H, Holmqvist M, Karlson EW, Alfredsson L, Bengtsson C; EIRA Study Group.

Ann Rheum Dis. 2013 Jul 25. doi: 10.1136/annrheumdis-2013-203567. [Epub ahead of print]

Regional differences regarding risk of developing rheumatoid arthritis in Stockholm County, Sweden: results from the Swedish Epidemiological Investigation of Rheumatoid Arthritis (EIRA) study.

Källberg H, Vieira V, Holmqvist M, Hart JE, Costenbader KH, Bengtsson C, Klareskog L, Karlson EW, Alfredsson L.

Scand J Rheumatol. 2013;42(5):337-43. doi: 10.3109/03009742.2013.769062. Epub 2013 Apr 23.

Non-participation in EIRA: a population-based case-control study of rheumatoid arthritis.

Bengtsson C, Berglund A, Serra ML, Nise L, Nordmark B, Klareskog L, Alfredsson L, Eira Study Group.

Scand J Rheumatol. 2010 Aug;39(4):344-6. No abstract available.

Environmental influences on risk for rheumatoid arthritis.

Liao KP, Alfredsson L, Karlson EW.

Curr Opin Rheumatol. 2009 May;21(3):279-83.

On the origins of complex immune-mediated disease: the example of rheumatoid arthritis.

Klareskog L, Wedrén S, Alfredsson L.

J Mol Med. 2009 Apr;87(4):357-62. Epub 2009 Jan 22.

Immunity to Citrullinated Proteins in Rheumatoid Arthritis. Annu Rev Immunol.

Klareskog L, Rönnelid J, Lundberg K, Padyukov L, Alfredsson L.

Annu Rev Immunol. 2008;26:651-75.

Genes, environment and immunity in the development of rheumatoid arthritis.

Klareskog L, Padyukov L, Rönnelid J, Alfredsson L.

Curr Opin Immunol. 2006 Dec;18(6):650-5. Epub 2006 Sep 28. Review.

Mechanisms of disease: Genetic susceptibility and environmental triggers in the development of rheumatoid arthritis. R

Klareskog L, Padyukov L, Lorentzen J, Alfredsson L.

Nat Clin Pract Rheumatol. 2006 Aug;2(8):425-33. Review.

What precedes development of rheumatoid arthritis?

Klareskog L, Alfredsson L, Rantapaa-Dahlqvist S, Berglin E, Stolt P, Padyukov L.

Ann Rheum Dis. 2004 Nov;63 Suppl 2:ii28-ii31. Review.

Genes and environment in arthritis: can RA be prevented?
Klareskog L, Lorentzen J, Padyukov L, Alfredsson L.

Arthritis Res. 2002;4 Suppl 3:S31-6. Epub 2002 May 9. Review.

RA and other diseases

Prevalence of Periodontitis in Patients with Established Rheumatoid Arthritis: A Swedish Population Based Case-Control Study.

Eriksson K, Nise L, Kats A, Luttropp E, Catrina AI, Askling J, Jansson L, Alfredsson L, Klareskog L, Lundberg K, Yucel-Lindberg T.

PLoS One. 2016 May 20;11(5):e0155956. doi: 10.1371/journal.pone.0155956. eCollection 2016.

Risk factors for the rapid risk increase of acute coronary events in patients with new-onset rheumatoid arthritis: A nested case-control study.

Mantel Ä, Holmqvist M, Nyberg F, Tornling G, Frisell T, Alfredsson L, Askling J.

Arthritis Rheumatol. 2015 Jul 2. doi: 10.1002/art.39267. [Epub ahead of print]

Recent infections are associated with decreased risk of rheumatoid arthritis: a population-based case-control study.

Sandberg ME, Bengtsson C, Klareskog L, Alfredsson L, Saevarsdottir S.

Ann Rheum Dis. 2015 May;74(5):904-7. doi: 10.1136/annrheumdis-2014-206493. Epub 2015 Feb 5.

Recent infections are associated with decreased risk of rheumatoid arthritis: a population-based case-control study.

Sandberg ME, Bengtsson C, Klareskog L, Alfredsson L, Saevarsdottir S.

Ann Rheum Dis. 2015 Feb 5. pii: annrheumdis-2014-206493. doi: 10.1136/annrheumdis-2014-206493. [Epub ahead of print]

Occurrence and relative risk of stroke in incident and prevalent contemporary rheumatoid arthritis.

Holmqvist M, Gränsmark E, Mantel A, Alfredsson L, Jacobsson LT, Wallberg-Jonsson S, Askling J.

Ann Rheum Dis. 2012 May 18. [Epub ahead of print]

Rapid increase in myocardial infarction risk following diagnosis of rheumatoid arthritis amongst patients diagnosed between 1995 and 2006.

Holmqvist ME, Wedrén S, Jacobsson LT, Klareskog L, Nyberg F, Rantapää-Dahlqvist S, Alfredsson L, Askling J.

J Intern Med. 2010 Aug 4. [Epub ahead of print]

No increased occurrence of ischemic heart disease prior to the onset of rheumatoid arthritis: results from two Swedish population-based rheumatoid arthritis cohorts.

Holmqvist ME, Wedrén S, Jacobsson LT, Klareskog L, Nyberg F, Rantapää-Dahlqvist S, Alfredsson L, Askling J.

Arthritis Rheum. 2009 Oct;60(10):2861-9.

Specific association of type 1 diabetes mellitus with anti-cyclic citrullinated peptide-positive rheumatoid arthritis.

Liao KP, Gunnarsson M, Källberg H, Ding B, Plenge RM, Padyukov L, Karlson EW, Klareskog L, Askling J, Alfredsson L.

Arthritis Rheum. 2009 Mar;60(3):653-60.

STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus.

Remmers EF, Plenge RM, Lee AT, Graham RR, Hom G, Behrens TW, de Bakker PI, Le JM, Lee HS, Batliwalla F, Li W, Masters SL, Booty MG, Carulli JP, Padyukov L, Alfredsson L, Klareskog L, Chen WV, Amos CI, Criswell LA, Seldin MF, Kastner DL, Gregersen PK.

N Engl J Med. 2007 Sep 6;357(10):977-86.

MHC2TA is associated with differential MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction.

Swanberg M, Lidman O, Padyukov L, Eriksson P, Akesson E, Jagodic M, Lobell A, Khademi M, Borjesson O, Lindgren CM, Lundman P, Brookes AJ, Kere J, Luthman H, Alfredsson L, Hillert J, Klareskog L, Hamsten A, Piehl F, Olsson T.

Nat Genet. 2005 May;37(5):486-94. Epub 2005 Apr 10.